Neuromodulators and Hyaluronic Acid Fillers

Do wrinkles form in the corners of your eyes when you squint or smile? Have the creases in your chin become more visible? Have your cheeks lost their plumpness? As we notice the changes in our skin caused by aging, it’s only natural to explore solutions that can revitalize and rejuvenate our skin to seemingly turn back the hands of time.

Without a doubt, research, word-of-mouth, and advertising will put dermal fillers and brands like BOTOX® on your radar. Before deciding on a procedure, it’s crucial to understand the difference between the many injectable filler options. There are many procedures out there claiming to smooth out lines and creases, improve facial symmetry, restore volume, and plump thin lips; however, they’re not all created equal nor are they all FDA-approved. They also use different technologies and ingredients to deliver results.

In this guide, we’ll discuss the different types of neuromodulators, hyaluronic acid fillers, and other forms of injectable cosmetic fillers.


Neuromodulators relax the muscle tissue to soften dynamic wrinkles, frown lines, and crow’s feet. Dynamic wrinkles are the wrinkles that form when you use your facial muscles to make expressions such as a frown. When our skin is younger, it can spring back to its original smoothness after we make these facial expressions.

As we age, these wrinkles no longer bounce back, remaining on the skin; at this point, they’re now referred to as static wrinkles. Static wrinkles are lines that seem to be etched into the skin and will most often be noticed in the forehead, between the brows and around the eyes. They are present even when you’re not making any facial gestures. Neuromodulators may improve static wrinkles as well; however, neuromodulators’ main effect is on the dynamic wrinkles.

BOTOX® is one of the most popular and most identifiable brands of neuromodulators, with over 6 million treatments done each year! It’s so popular that people ask for the treatment by name. According to the BOTOX official website, “Only BOTOX® Cosmetic is FDA-approved to temporarily make moderate to severe frown lines, crow’s feet, and forehead lines look better in adults.”

Two other common brands of neuromodulators are Dysport and XEOMIN. Dysport specifically targets the frown lines between the eyebrows, treating the facial muscles without giving you the “frozen look.” Dysport is extremely similar in its composition compared to BOTOX®; however, both have various levels of effect on different areas of skin.

XEOMIN is advertised as the “only clinically proven anti-wrinkle injection uniquely purified to remove unnecessary proteins.” XEOMIN, a highly purified neurotoxin, softens frown lines by blocking the release of the chemicals that cause the muscle contractions. XEOMIN is FDA-approved for the treatment of patients with sialorrhea; however, it is also used for cosmetic indications such as moderate to severe frown lines between the eyebrows.

Hyaluronic Acid Fillers

Hyaluronic Acid (HA) is a naturally occurring substance found in the body that helps your cells retain moisture, giving your skin that hydrated, radiant, and plump appearance. As we age, the hyaluronic acid levels in the body decrease, resulting in visible signs of aging such as wrinkles.

There are many brands of HA fillers, such as JUVÉDERM®, TEOSYAL®, Restylane, and many others. HA fillers aim to restore the lost volume by stimulating collagen production, effectively enhancing the appearance of a sunken or sagging face. By temporarily replacing volume, HA fillers can be used to contour and create structure in the face.

With the right techniques and skills, HA fillers can be used to lift and tighten, softening shadows, hollows, and folds. Directly injecting into hollows and folds without lifting and tightening first may lead to inferior, unnatural-looking results. One also has to be mindful of how the face will look when moving or expressing emotions after the filler has been injected. HA fillers can be dissolved or partially removed using an enzyme called hyaluronidase.

JUVÉDERM® can add volume to lips, smooth lines, and contour cheeks. TEOSYAL️® is a range of injectable HA-based fillers designed to treat wrinkles, give volume to the face, and improve skin quality. TEOSYAL®RHA is a wrinkle filler that claims to be the “first dermal filler specifically designed with high strength and high stretch properties developed with the objective of mimicking the natural HA in our skin.”

The Restylane range of dermal fillers is designed to help to restore volume lost to aging, enhance face shape and definition, refresh and improve the condition of the skin to achieve the appearance of radiant and hydrated skin.

Restylane is most commonly used to treat specific areas such as the cheeks, mouth, nose folds, lips, and areas around the eyes.

To achieve the most natural results, injecting HA fillers requires an understanding of a process called “myomodulation.” Myomodulation is a process that affects how muscle moves when fillers are injected, either above or below the muscle tissue and along the length of the muscle fibers.

Other Types of Injectable Cosmetic Fillers

Sculptra is an injectable cosmetic filler used to restore facial volume lost to aging. The active ingredient in Sculptra is poly-L-lactic acid (PLLA), a synthetic substance that stimulates collagen production. It’s FDA-approved under the brand name Sculptra Aesthetic for the restoration and correction of deep nasolabial folds, wrinkles, and facial fat loss.

RADIESSE® is another FDA-approved dermal filler that smooths moderate to severe facial wrinkles and folds such as the creases around the mouth. RADIESSE® contains microspheres of calcium hydroxylapatite, a type of mineral that’s found in human teeth and bones. Similar to Sculptra, RADIESSE® stimulates the natural production of collagen to restore lost volume in the face, making it an ideal treatment for Marionette lines, pre-jowl folds, chin wrinkles, and smile lines.

Bellafill is an FDA-approved filler to smoothen smile lines for up to 5 years; it’s also the only FDA-approved long-term solution for acne scars. Bellafill is an injectable filler with a collagen base and polymethyl methacrylate (PMMA) microspheres; once injected, its collagen gel reduces the look of smile lines and uses the microspheres to stimulate your collagen to develop naturally. As a solution for acne scars, it adds volume to level the surrounding skin.

Are you ready to discover the right procedure for you? At CüR Laser and Skin, we believe that aging is inevitable, but skin imperfections don’t have to be. Dr. Kumar has completed thousands of safe and pain-free cosmetic procedures with phenomenal results every year.

Feel good about aging with the help of CüR Laser and Skin. Schedule a consultation now.

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